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nasdaq:adap adaptimmunellc.applytojob.com adaptimmunellc.applytojob.com Aug 14th, 2018 12:00AM Senior Scientist, Gene Editing Open Research Abingdon Oxfordshire GBR PRIMARY RESPONSIBILITY The goal of the Gene Editing team is evaluate various editing technologies/methods to enable Adaptimmune to develop an “off the shelf” T cell product derived from stem cells or mature T cells.  If successful, this could significantly reduce the time/cost to treat patients improving patient access to T cell therapy.   Gene editing is an integral part of the process to develop a cell product that can be given to any patient and shows good efficacy and persistence.  The gene editing will either be performed in stem cells, followed by single cell cloning to produce master and working cell banks which can be differentiated into T-cells or in bulk T cell populations from healthy donor apheresis. The responsibilities of this role are to work within the Gene Editing team conducting scientific experiments and developing assays as required to evaluate different editing platforms. The role will be expected to contribute to the execution of the gene editing required for Stem Cell Research working extremely closely with colleagues in other R & D teams as part of a cross functional project team.   KEY RESPONSIBILITIES Conducting experiments in molecular biology and cell labs (65%) Experiment planning, data analyses and recording results (20%) Meetings and discussions (10%) Routine lab maintenance (5%)   QUALIFICATIONS & EXPERIENCE Required •  Degree in Lifesciences or related discipline •  Extensive relevant post-graduate experience, possibly including an MSc or PhD in a relevant scientific area •  Understanding and practical experience of gene editing and molecular characterisation of edited cells •  Extensive experience of relevant laboratory procedures •  Ability to work independently on routine experiments •  Ability to learn and develop in order to work independently on non-routine experiments within a reasonable time frame •  Aseptic cell culture experience Desirable •  Experience with design and construction of viral and/or non-viral expression vectors •  Background in AAV production and purification •  Experience in stem cell culture •  Experience of generating genetically modified cell lines from single cell clones   SKILLS & COMPETENCIES Required •  Molecular Biology skills – DNA/RNA purification, cloning, PCR, qPCR, DNA sequence analysis •  Culture and transfection of transformed and primary human cells •  Computer literacy and ability to familiarise with different IT and database systems •  Excellent numeracy and English language skills (both written and verbal) •  Excellent communication skills (both written and verbal) •  Ability to follow protocols, record data and enter reagents into appropriate databases •  Knowledge and skills to use standard laboratory equipment (such as pipettes, pH meters, centrifuges etc) •  Ability to design and troubleshoot experiments and studies to address key scientific questions •  High attention to detail, good time management skills and communication skills •  Able to work independently after training •  Strong team player but with the ability to work independently •  Disciplined, innovative, flexible and highly motivated Desirable •  Southern Blot (non-radiolabelled) •  Single cell cloning •  Single cell PCR •  Familiarity with flow cytometry and cell sorting •  Fluorescence microscopy Aug 13th, 2018 10:13PM Aug 13th, 2018 10:13PM Health Care Pharmaceuticals & Biotechnology
nasdaq:adap adaptimmunellc.applytojob.com adaptimmunellc.applytojob.com Aug 14th, 2018 12:00AM Scientist, Histology and Gene/Protein Expression Analysis Open Research Abingdon Oxfordshire GBR Primary Responsibility This role is based within our Target Validation group who are responsible for the identification and characterization of tumour antigens. Desirable skills for this group include those related to histology and gene/protein expression analysis. The purpose of this role is to primarily conduct scientific experiments as necessary within dedicated scientific and project teams.   Whilst initially requiring supervision by a more senior scientist, the job holder will develop further scientific skills to be able to work more independently on routine experiments and on the interpretation of scientific results.    The scientist may also be involved in one or more support activities to enable the smooth running of the group or laboratory and enabling company functioning toward its goals (e.g. Lab steward role).   Key Responsibilities Conducting experiments and supporting colleagues, the group and Adaptimmune projects. In collaboration with the Senior Scientists and Principal Scientists, analyse, summarise and record experimental results and maintain relevant databases and records. Participate in group and project meetings and discussions.  Routine lab maintenance.   Qualifications & Experience Minimum Required Degree in Life Sciences. Previous working experience within a laboratory (either academic or industry). Ability to work independently on routine experiments with limited supervision   Desirable Additional post-graduate scientific experience or qualifications, such as an MSc. or PhD Previous experience in histological techniques and/or gene/protein expression analysis: RT-PCR and qPCR, western blot, processing of samples (fixing, embedding and sectioning), immunohistochemistry, in situ hybridisation and bright/fluorescent microscopy, etc.   Skills & Competencies Required Computer literate and ability to familiarise with different IT systems Excellent numeracy and English language skills (both written and verbal) Excellent communication skills (both written and verbal) Ability to follow protocols. Knowledge and skills to use of standard laboratory equipment (such as pipettes, pH meters, centrifuges). Basic experimental design skills (use of controls, etc.), attention to detail, good time management skills, team player attitude, good communication skills. Able to work independently after training. Strong team player but with the ability to work independently as well.   Desirable Use of more specialist lab equipment (i.e., auto-stainer, histology imaging scanner, qPCR system, etc.). Aug 13th, 2018 10:13PM Aug 13th, 2018 10:13PM Health Care Pharmaceuticals & Biotechnology
nasdaq:adap adaptimmunellc.applytojob.com adaptimmunellc.applytojob.com Aug 15th, 2018 12:00AM Contract Supply Chain Specialist, Vector Manufacturing Open Manufacturing Stevenage Hertfordshire GBR Primary Responsibility Plan and manage the material supply chain supporting the Vector manufacturing facility for Adaptimmune, a genetically engineered autologous cell therapy company.  This facility is based at the Catapult site in Stevenage.   Key Responsibilities Design, maintain, and own the production schedule for Catapult manufacturing.  Communicate and coordinate the production schedule with cross-functional business partners.  Work with sourcing and procurement to optimize required inventory holding and reorder points for all materials needed to support manufacturing.. Maintain item master/material master data.  Ensure master data is accurate and up to date (i.e. Part numbers, bills of materials, vendor details).  Manage change controls for the updating of item and material master data. Develop and track supply chain and manufacturing Key Performance Indicators and data, including inventory, cycle time, and asset utilization/capacity reports.  Partner with Catapult team to develop and align on Operational KPIs for warehouse. Work with manufacturing to develop capacity requirements based on patient forecasts. Monitor, order, reorder, and maintain inventory of process gases, raw materials, consumables, gowning materials, cleaning agents and other supplies that are required to support Manufacturing and Laboratory Operations. Secure materials, as needed, from Catapult warehouse airlock.  Ensure accurate cycle count and organized storage of materials.  Investigate and reconcile any inventory discrepancies that are discovered. Support shipping process by managing all inbound deliveries of raw materials, and also managing outbound shipments of manufacturing product and samples. Perform other supply chain planning/analysis as required.   Qualifications & Experience Required: Bachelor’s degree in business, operations, supply chain, or applicable discipline Previous experience in a supply planning/materials management role Strong analytical/data management skills (i.e. Microsoft Access, Excel)   Desirable: Experience with  biopharmaceutical operations Experience with ERP/Supply chain systems and tools MBA     Skills & Competencies Required: Strong interpersonal and communication skills (both spoken and written) Highly motivated, independent and a self-starter Detail oriented Sense of urgency and ability to work effectively to timelines Comfortable with ambiguity—able to work effectively in an evolving and dynamic environment   Desirable: Strong relationship building skills—collaborates effectively with others, both internally and externally. Working knowledge of finance and budgeting Effective negotiation skills with ability to employ different styles and/or strategies to influence others Ability to operate both strategically and tactically—understands and communicates the big picture while willing to roll up sleeves to get work done Aug 14th, 2018 10:24PM Aug 14th, 2018 10:24PM Health Care Pharmaceuticals & Biotechnology
nasdaq:adap adaptimmunellc.applytojob.com adaptimmunellc.applytojob.com Aug 15th, 2018 12:00AM Financial Reporting Accountant Open Finance Abingdon Oxfordshire GBR Primary Responsibility To prepare the financial statements for external quarterly and annual reporting, including disclosures to a high standard and compliant with US GAAP.  Preparing monthly accounting entries for complex accounting areas and providing assistance with researching and documenting technical accounting issues.   Key Responsibilities Preparation of quarterly and annual financial statements for UK and US reporting, including preparation of primary statements and disclosures, disclosure checklist, managing input from stakeholders and XBRL process. Involvement in the monthly close process including complex areas, such as revenue recognition, foreign exchange, share-based payments, EPS, tax and investments. Assisting with researching and documenting technical accounting issues, including the adoption of new standards and maintaining the Company’s Accounting Manual. Ad hoc projects   Qualifications & Experience Required : University degree Chartered Accountant (ACA Qualified) Experience of IFRS or US GAAP Experience of listed company reporting (either through audit or at a listed company)   Desirable Experience of US GAAP Experience of Sox compliance (either through audit or at a company) Experience of consolidations Aug 14th, 2018 10:24PM Aug 14th, 2018 10:24PM Health Care Pharmaceuticals & Biotechnology
nasdaq:adap adaptimmunellc.applytojob.com adaptimmunellc.applytojob.com Aug 15th, 2018 12:00AM IT Manager – Vector Manufacturing Systems Open Information Management Abingdon Oxfordshire GBR PRIMARY RESPONSIBILITY This position is a technically oriented role and will perform as hands-on technical analyst and IT systems owner to provide IT operational support for Manufacturing Operations which includes all IT systems, solutions, and applications across Vector Manufacturing and Process Development functions.   Key responsibilities include: Execute daily IT operations (e.g. configuration, administration, master data management, etc.) of all IT systems and services in scope.   Trouble-shoot and resolve Tier 2 through 3 tickets with vendors.  Author business and technical requirements Execute efficient and effective operational IT processes that adapt to the dynamics of the business Deliver to best practices in IT architecture, IT security, GxP compliance, and IT production operations. Execute IT software development lifecycle (SDLC) methodology to deliver new solutions and system enhancements.    Follow IT GxP procedures. Collaborate with Business Systems Owners and IT colleagues As IT owner of established systems, accountable to ensure such systems are fit-for-purpose for our business processes, and serve as main point of contact for escalation of any system issues, data integrations and system enhancements.  Participate in new systems implementations as business and systems analyst.     KEY RESPONSIBILITIES 1  IT Operations (70%) - Provide hands-on operational support (technology, out-of-the-box configurations, process and content) for installed solutions.  Author GxP business and technical requirements, use cases, process flow document, create robust test plans and scripts, execute testing, support user acceptance testing, and perform production rollout.   Responsible for maintaining systems documentation, and adherence to IT Policies, SOPs, compliance standards, GxP requirements and change controls. Provide technical consulting and perform user training with Business System Owner as needed.  2  Business Partnering and Solutioning (10%) - Responsible for understanding business problem to be solved, the end-to-end business processes, dataflow and conditions.   Apply business process improvement methods to optimize business processes using best practices. 3  Implementation (20%) – Provide support during new systems implementation process, overseeing development or configuration to ensure the solutions are built and will meet/exceed the needs of the business.   Own and create test plans, user acceptance tests, and coordinate training and roll-out.   QUALIFICATIONS & EXPERIENCE Required •  Bachelor’s Degree in Computer Science/Information Systems related or equivalent experience •  Solid experience in IT Operations role supporting Biotechnology or Pharmaceutical manufacturing operations function, and experience in related packaged applications, systems, business process and IT process. •  Solid hands on experience with GxP and regulated systems, including execution of IT computer systems validation deliverables and process •  Demonstrated experience in IT systems operations, new systems implementation, and IT software development lifecycle •  Proven ability to effectively own and support multiple systems •  Strong cross-functional and IT analyst skills. •  Strong process mapping ability, and ability to see the big picture •  Technical experience (administration, configuration, meta-data management, etc.) with any or all of these manufacturing oriented GMP solutions:  MES, QC sample management, environmental controls (BMS), scheduling, GMP equipment maintenance, inventory management, change control, isolated networks, bar coding, quality process management software   Desirable •  MBA or advanced degree •  Information Security experience is a plus. •  Cloud based software applications, packaged application, platform implementations, or custom development experience   SKILLS & COMPENTENCIES Required •  Highly energetic, passionate champion for the business and an ability to quickly establish credibility •  Understanding of Manufacturing Execution Systems, ERP and Laboratory Information Management Systems •  Strong ability to identify/anticipate opportunities, problems and road blocks, maintains a solution focused approach and develops plans accordingly. •  Ability to bring people together and communicate technical language in a non-technical manner. •  Ability to communicate with individuals and groups about their needs, identify essential requirements and implement solutions. •  Demonstrated hands-on experience creating business requirements, functional requirements, process maps, test plans, and test scripts •  Ability to interact effectively as individual contributor or as a member of a team. •  Able to work in a fast paced deadline driven environment. •  Work on complex and abstract problems independently where decisions are based upon a mixture of analysis, wisdom, experience, judgment and rigorous logic and methods. •  Meet deadlines and deliver quality work, even under pressure. Desirable •  Involved in a Manufacturing Site Startup Technical programming skills related to any or all of these manufacturing oriented GMP solutions:  QC sample management, environmental controls (BMS), scheduling, GMP equipment maintenance (CCMS), inventory management, change control, isolated networks, bar coding, quality process management software Aug 14th, 2018 10:24PM Aug 14th, 2018 10:24PM Health Care Pharmaceuticals & Biotechnology
nasdaq:adap adaptimmunellc.applytojob.com adaptimmunellc.applytojob.com Aug 15th, 2018 12:00AM Senior Informatician – Research Data Science Open Information Management Abingdon Oxfordshire GBR Primary Responsibility The Senior Informatician will provide expert guidance and support the planning and execution of computational research and bioinformatics projects, strengthen cross-functional matrix ways of working, and drive the strategic advancement of our Research Data Science capabilities.   This role will operate from a central group orientation and is intended to make significant contributions in elevating our computational-bioinformatic-scientific team-work, process and methods, life-cycle and tools for understanding biological data.  The Sr. Informatician will establish centralized goals and objectives for Research bioinformatics staff in partnership with Research line managers to advance common ways of working and drive overall effectiveness to achieve outcomes.    Key responsibilities: Provide scientific computing wisdom, expertise and guidance to computational researchers and bioinformaticians, scientists, and line leaders in the plan, design, execution and interpretation of biologic data Through a scientific computing lens, lead the computational-bioinformatic evaluation, implementation and roll-out of enterprise tools, data sources, best practices, methods, life-cycle approaches, and TBD advanced solutions to elevate our bioinformatic analytic capabilities (people, process and technology) Hands-on execute any bioinformatic projects in support of broad Research goals, as assigned In addition to Research staff, this role will partner with internal and external centralized software engineers, data engineers, data architects, project managers, data stewards and governance resources to deliver on a strategic enterprise vision around integrated bioinformatics data insight in support of line functions, who make meaning of the data.  The Senior Informatician must be at ease shifting through project execution, mentoring of senior and junior staff, matrix structures, and the stand up of new centralized enterprise capabilities to better achieve analytic outcomes.   The role will be highly visible, and therefore is expected to positively impact the overall execution of Research Data Science projects and delivery of enterprise capabilities.   Key Responsibilities Provide scientific computing wisdom, expertise and guidance to computational researchers and bioinformaticians, scientists, and line leaders in the plan, design, execution and interpretation of biologic data Build strong relationships with Research leaders, scientists, computational researchers, bioinformaticians, and central group staff to execute as a credible senior internal expert In a consultative fashion, provide strategic, tactical, operational, and lifecycle expertise to bioinformatics and computational research projects staffed by line function resources Oversee the computational-bioinformatic deliverables of external specialists on behalf of line function Actively participate as an integral member of key efforts to ensure that advanced computational biology considerations are highly visible in both team strategies and line decision making Partner with cross-functional research teams to understand their near-term scientific and technical challenges and identify where advanced data science can best make an impact on achieving goals Develop new approaches to continuously improve quality, effectiveness and speed of computational initiatives, and deploy a sustainable repeatable cross-functional bioinformatics life-cycle Drive cross-functional ways of working and coach research staff members for maximal success, and adoption of centralized capabilities, advanced methods and best practices Thoughtfully and pragmatically pull through change management activities Coach and mentor line function staff on use of various data analysis tools and methodologies Support the professional development of Bioinformaticians and Computational Researchers Formalize central Research Data Science Bioinformatician goals and objectives in partnership with Research Line Managers, and oversee the achievement of those objectives in matrix structure Role model desired matrix-centralized ways of working   Through a scientific computing lens, lead the computational-bioinformatic evaluation, implementation and roll-out of enterprise tools, data sources, best practices, methods, life-cycle approaches, and TBD advanced solutions to elevate our bioinformatic analytic capabilities (people, process and technology) Develop a deep understanding of key Research programs, and understand the data and scientific inter-dependencies across projects to form a bigger picture  Clearly translate big picture Research vision to enterprise bioinformatics solutions while balancing risk, fit for purpose and desired outcomes (short, mid and long-term) Own enterprise scientific computing tools plan, and advocate line function needs to the central group in order to prioritize new capabilities Partner with delivery teams to incorporate new tools into day-to-day line operations and projects Champion innovative open source and commercial solutions to improve operational execution Own internal / external enterprise data sources across research functions to better deploy analytic investments and integrate our data (software, database, infrastructure and integration tools) Train our bench science community in the tools critical to understanding their data Work closely with software developers and IT professionals to create custom toolkits and analytic methods to meet the needs of line functions In partnership with Central Project Manager, present central projects to broad audiences, communicate updates, milestones, value and roadblocks to senior management   3. Hands-on execute start-to-finish any complex bioinformatic projects, as assigned or as needed based on key Research objectives   4  Other duties as assigned by management in support of rapidly growing company   Qualifications & Experience. Required Masters degree in Bioinformatics, Computational Biology, Information Technology or related field or equivalent postgraduate experience, preferably in a laboratory science environment Extended experience in Next Generation Sequencing-RNA seq data analysis and other bioinformatics tools Expert in single and multi-mode deep biologic data analysis and interpretation Able to proactively seek collaborations with scientists and lab heads Strong initiative, excellent interpersonal and communication (written and oral) skills Strong influencing skills, and desire to effect positive change across several functions Expertise in algorithmic implementation, statistical programming and multi-mode data manipulation Familiar with specialized commercial and open source data visualization and analysis tools Solid understanding of bioinformatics-computational experimental design Deep knowledge of cancer genomic data sources and data integration-interpretation tools. Demonstrated ability to derive molecular signatures of drug response, such as the application of machine learning techniques to drug response and multi-omics datasets Strong problem-solving skills, collaborative nature and the ability to lead through influencing An understanding of tools for the analysis of high dimensional data High energy, confident, gets things done, yet easy going personality At ease in matrix environment with dotted line management responsibility   Desirable Extensive post-graduate experience in computational biology and bioinformatics Deep understanding of computational methods, scripting and programming languages, and relevant concepts in cancer biology, immunology and/or genetics Demonstrated success in achieving key milestones and contributions to the field Excellent leadership capabilities with skill in building, guiding and motivating effective teams and fostering productive scientific computing-research collaborations Proven ability to hire, coach and develop world class talent Outstanding communication and partnering skills Prior experience implementing centralized integrated data and analytics tools Experience in biotechnology field     Skills & Compentencies Required Knowledge of all components of holistic computational research / bioinformatic architecture, business engineering principles, advanced methods, experimental scientific design and related processes Familiarity with IT practices, system development life cycle management, infrastructure and operations Exposure and understanding of existing, new and emerging technologies, and processing environments Exceptional soft and interpersonal skills, including teamwork, facilitation and negotiation Expert with graphical modelling approaches, tools and model repositories Organizationally savvy, and understanding of the political climate of the enterprise and how to navigate obstacles and politics Ability to balance the long-term ("big picture") and short-term implications of individual decisions Ability to translate various scientific needs into cohesive picture Ability to apply multiple solutions to business problems Ability to rapidly comprehend the functions and capabilities of new technologies Ready to think, behave and act in an innovative consulting manner to drive the organization's strategies Understand and speak the language of the research, IT and bioinformatics Effective at driving short-term actions that are consistent with long-term goals Demonstrate the ability to work well with others and be respected as a leader Have a track record of remaining unbiased toward specific technologies or vendors Be an excellent communicator and collaborator across multiple technical stakeholders and leaders Be able to translate the data architecture contribution to business outcomes into simple briefings Effective conceptualization, pattern recognition and design-thinking skills Data integration experience, including interface design, and familiarity with web-oriented architecture techniques Understanding of metamodels, taxonomies and ontologies, as well as of the challenges of applying structured techniques (data modelling) to less-structured sources Familiarity with master data, business intelligence, data lake, and data warehouse techniques Ability to assess rapidly changing technologies and apply them to business needs Strong communication and persuasion skills, including the ability to create marketing and messaging materials that meet stakeholder preferences. Enthusiastic to work as part of cross disciplinary multi-function centralized team in support of Research   Desirable Trusted and respected as a thought leader who can influence and persuade research scientists and IT leaders and key personnel Comfortable, experienced and accomplished at working with business executives, and able to push back in a professional and diplomatic way Highly collaborative and supportive of business and of its ideals and strategies Vendor- and technology-neutral — more interested in business outcomes than in personal, or those business and IT leaders with vested personal preferences Unflappable in the face of opposition to vision, future ways of working ideals, and build lead times Practical in approach to decision making, recommendations and problem solving that is principle-based An understanding of the principles of oncology / immunoncology Prior experience in complex biotechnology and / or pharmaceuticals industry Aug 14th, 2018 10:24PM Aug 14th, 2018 10:24PM Health Care Pharmaceuticals & Biotechnology
nasdaq:adap adaptimmunellc.applytojob.com adaptimmunellc.applytojob.com Aug 15th, 2018 12:00AM Associate Director – Research Data Science Open Information Management Abingdon Oxfordshire GBR Primary Responsibility The Associate Director will provide operational leadership, project-portfolio management and governance support for Research scientific computing projects, cross-functional matrix ways of working and the strategic advancement of our computational research and bioinformatics activities.  Key business partners of this role are computational researchers, bioinformaticians, functional line leaders and senior scientific staff.  This role will operate from a central group orientation and is intended to make significant contributions in elevating how we execute and deliver on our understanding of biological data under the broad lens of our Research Data Science and enterprise data vision.  Key responsibilities: Steer central-shared ways of working  (e.g. data governance, project governance, project prioritization, risk management, resource allocation, team-work and unity, communication-transparency, tool standardization) in order to treat Research biological data and analytical insight as a sustainable Company asset, and to optimize scientific computing outcomes Pragmatically and thoughtfully execute as senior change agent in a matrix environment Hands-on organize and manage a portfolio of work comprised of line, cross-functional and centralized scientific computing projects on behalf of the Research function and Central group Using good project management techniques, lead the delivery of new enterprise scientific computing tools and data sources to elevate our bioinformatics-computational analytic capabilities (people, process and technology) Manage external strategic vendor and resource support for computational research-bioinformatic-scientific computing projects In additional to Research staff, this role will partner with internal and external centralized software engineers, bioinformaticians, data engineers, data architects, data stewards and governance resources to deliver on a strategic enterprise vision around integrated data insight in support of line functions, who make meaning of the data.  The Associate Director must be at ease sorting out complex and sometimes unpredictable projects and priorities, coaching senior and junior staff, leading in a matrix structure, governance, and standing up of new centralized enterprise capabilities to better achieve biologic analytic outcomes.    The role will be highly visible, and therefore is expected to positively impact the overall day-to-day execution of Research bioinformatics projects and delivery of enterprise capabilities. 1, Steer central-shared ways of working  (e.g. data governance, project governance, project prioritization, risk management, resource allocation, communication-transparency, tool standardization) in order to treat Research biological data and analytical insight as a sustainable Company asset, and to optimize scientific computing outcomes Build and maintain strong relationships with key Research leaders, wet scientists, computational researchers, bioinformaticians, and central group staff to bring to life a sustainable unified approach Partner with cross-functional and line research teams to understand their near-term scientific and technical challenges and identify where advanced data science can best make an impact on achieving goals Stand up and run central operations-governance processes and procedures while making transparent decision making, prioritization, resource allocation, timelines and challenges Coach staff members in adoption of matrix and centralized governance ways of working Present clearly and succinctly in a variety of internal settings 2. Pragmatically and thoughtfully execute as senior change agent Develop a deep understanding of key Research programs, and understand the data and scientific inter-dependencies across and within projects to form a bigger picture.   Effectively summarize and communicate areas of need (short, mid and long term) in approved project work. Create formal change management plans, and deliver on plans into business as usual operations Execute the soft side of change management, and help colleagues sort through difficult change events Role model desired matrix / centralized ways of working 3. Hands-on organize and manage a portfolio of work comprised of line, cross-functional and centralized scientific computing projects on behalf of the Research function and Central group Deploy a lean project management approach that does not get in the way of the science Own repeatable mechanisms to centrally prioritize, report on and resource approved project work with senior management, stakeholders and line leads Plan and lead individual projects and a collection of projects with Research staff using mix of repeatable project, program and portfolio management skills and techniques Own and facilitate centralized timelines for Research bioinformatics projects, maintain project momentum and forward progress, and routinely summarize status for stakeholders and senior leaders using scorecards and lean project management techniques Drive good decisions, communicate up-down-sideways milestones, create transparency into the work, and identify timeline, budget, resource, scientific or inter-dependency or cross-functional challenges Lead the project teams to determine alternative solutions and provide recommendations for resolution or escalate of risks and challenges, as necessary Role model desired matrix / centralized ways of working 4, Using good project management techniques, lead the delivery of new enterprise scientific computing tools and data sources to elevate our bioinformatics-computational analytic capabilities (people, process and technology) Represent line function needs to the central group in order to prioritize capability plan-build Translate big picture research vision to enterprise bioinformatics solutions while balancing risk, fit for purpose and desired outcomes (short and mid-term) Champion innovative solutions that align with research needs (today and tomorrow) Present central group scientific computing capabilities build out and deployment plans to broad audiences, communicate updates, milestones, and roadblocks to senior management and line leads Effectively develop, manage detailed project plans, identifying and removing project roadblocks, and maintaining project momentum and forward progress Analyze project issues or risks, lead the project team to determine alternative solutions and provide recommendations for resolution or escalate, as necessary Create project deliverables including but not limited to business requirements, functional requirements, process maps, test plans, and test scripts Communicates effectively with internal customers and all levels of management  5. Manage external strategic vendor and resource support for computational research-bioinformatic-scientific computing projects Manage process to quickly define external specialist requirements, and on-board resources Own external strategic vendor relationships and direct external bioinformatic specialists on behalf of line functions and central group Coordinate with Sr. Informatician, who owns the scientific computing oversight of external resource deliverables 6. Other duties as assigned by management in support of rapidly growing company   Qualifications and Experience Required: Bachelor’s Degree with substantial leadership-management experience in Bioinformatics, Computational Biology, Computer Science, Information Systems or related field or equivalent postgraduate experience, preferably in a laboratory science environment Solid understanding of tools and methods for the analysis of high dimensional multi-mode and single mode biologic data Demonstrated experience in project-portfolio-program management methodologies and proven ability to manage multiple, complex data projects simultaneously in matrix structure Proven experience in change management activities and techniques Strong cross-functional leadership skills, ability to be role mode, strong influencing skills Ability to execute lean process, and engage with business partners using soft skills Must be familiar with the role and function of scientific team members in order to effectively coordinate the activities of the teams Proven experience with enterprise data-project governance and process and methodologies Demonstrated ability to work well with others, and be respected as a leader to drive unity and teamwork The ability to proactively seek collaborations with scientists, researchers and lab heads Strong initiative, excellent interpersonal and communication (written and oral) skills High energy, confident, gets things done, yet easy going personality At ease in fast paced matrix cross-functional environment Biotechnology background with experience in Research and Development Aug 14th, 2018 10:24PM Aug 14th, 2018 10:24PM Health Care Pharmaceuticals & Biotechnology
nasdaq:adap adaptimmunellc.applytojob.com adaptimmunellc.applytojob.com Aug 15th, 2018 12:00AM Senior Legal Administrator - 12 month (Contract to Perm possibility) Open Legal Abingdon Oxfordshire GBR PRIMARY RESPONSIBILITY Adaptimmune ar elooking for a Legal Administrator/Paralegal to join our small legal team in the Abingdon office.   This will be a 3 month contract role that may be extended or go temp to perm (no promises!) .  In this role you will  provide administrative support to legal team including contract administration and EA activities for members of legal team.   KEY RESPONSIBILITIES Managing diary and appointments for GC and other members of legal team, booking travel and providing executive assistance for members of legal team  –30% Processing contracts, arranging for execution of contracts, saving of contracts into appropriate databases, circulating fully executed agreements to correct internal and external parties, assisting with expiring confidentiality agreements and updating legal trackers – 30% Managing legal work flow and legal inbox, including assignment of tasks to legal team and prioritisation – 25% General administration support for legal team including assistance to paralegal function in UK and US, proof reading, agreement compiling, schedule checking, database administration - 15%   QUALIFICATIONS & EXPERIENCE Required Qualifications: Minimum 5 GSCE’s including English Language at Grade C or above. Solid experience as executive assistant experience supporting Legal/ Senior Management and/ or Executive Teams or have worked as a Paralegal. Competent user of Microsoft Office, Microsoft Excel, Outlook mail, calendar features, Adobe Acrobat.   Desirable Previous experience with case management systems Qualifications: NVQ 2/ 3 Business Administration   SKILLS & COMPETENCIES Required Ability to learn new skills quickly and able to contribute as a key team player and work independently. Must be reliable, enthusiastic and conscientious whilst displaying common sense and flexibility. Excellent organisational and prioritisation skills Ability to act in a professional manner and to maintain confidentiality and provide specified support in a fair and confident manner. Approachable and able to establish good working relationships with staff at all levels in the company. Ability to independently identify and resolve situations as they occur. Ability to produce consistently accurate work whilst under pressure and to manage competing responsibilities. Aug 14th, 2018 10:24PM Aug 14th, 2018 10:24PM Health Care Pharmaceuticals & Biotechnology
nasdaq:adap adaptimmunellc.applytojob.com adaptimmunellc.applytojob.com Aug 15th, 2018 12:00AM Scientist, Cell Process Development Open Process Development Abingdon Oxfordshire GBR Primary Responsibility Functional focus: The Cell Process Development team is concerned with the improvement and automation of our T cell manufacturing process.  Process development is assessed and evaluated through analysis of cell products, from various stages within the manufacturing process, by characterisation in phenotypical and functional assays. Process changes are then tech transferred to our global manufacturing teams.. The purpose of this role is to primarily conduct scientific experiments as necessary within dedicated scientific teams. Whilst initially requiring supervision by a more senior scientist, the job holder will develop further scientific skills to be able to work more independently on routine experiments. The job holder will also be responsible for the interpretation of scientific results under the supervision of a senior scientist..   Key Responsibilities Conducting experiments in cell culture and analytical labs (80%) Experiment planning, data analyses and recording results (10%) Meetings and discussions (5%) Routine lab maintenance (5%)   Qualifications & Experience Required: Degree in Lifesciences or related discipline Ability to work independently after training Aseptic cell culture experience, ideally large-scale and/or with primary human T cells Good understanding of cell biology   Desirable: Practical experience in relevant cell biology assays Relevant experience working in an academic or industrial lab environment Process development experience GMP/GLP experience   Skills & Competencies Required: Disciplined, innovative, flexible and highly motivated Strong team player but with the ability to work independently Strong communication skills (both written and verbal) are essential, as the team regularly interacts with research, preclinical and manufacturing groups internally and externally with CMOs and CROs. Ability to follow SOPs Problem solving abilities Good time management High attention to detail Computer literate and ability to familiarise with different IT and database systems Use of standard laboratory equipment (such as pipettes, centrifuges). Basic experimental design skills (use of controls, etc.)   Desirable Use of more specialist lab equipment (flow cytometers, cell counting equipment, cell washing and concentration equipment, bioreactors, ELISPOT and ELISA readers) Ability to write SOPs, study protocols and reports Advanced experimental design skills (suggestions for improvements, next steps,…) Technical interest Aug 14th, 2018 10:24PM Aug 14th, 2018 10:24PM Health Care Pharmaceuticals & Biotechnology
nasdaq:adap adaptimmunellc.applytojob.com adaptimmunellc.applytojob.com Aug 15th, 2018 12:00AM Scientist/Senior Scientist - Cell Biology. 14 month Contract Open Research Abingdon Oxfordshire GBR For this post we are seeking an experienced Cell Biologist to join a vibrant, fast moving and multi-disciplined cell biology team aimed at delivering a pipeline of new enhanced T cell receptor (TCR)-based therapies to the clinic. This role is being opened as a 14 month maternity cover contract, looking to start in October/November. This group is involved in identifying, characterising and safety testing optimal candidate TCRs for Adoptive T Cell Therapy.  The role will involve designing and carrying out experimental schedules involving a wide variety of cutting edge cellular and immunological assays to assess the efficacy and specificity of candidate TCRs. A flexible, enthusiastic, creative attitude to work, good data management skills, attention to detail and the aptitude to deal with multiple disciplines in parallel projects is essential.  Good time management and the capability to work to deadlines will also be key.   Skill sets required: Previous cell culture and in vitro assay experience is essential, and experience of one or more of the following would be useful but not essential as training will be provided: primary T cell culture cellular immunology ELISpot ELISA flow cytometry Candidates should have, or soon be completing, a PhD in a relevant subject within a cell biology research lab. Hepatitis B vaccination may be required and costs will be  covered by Adaptimmune if necessary Aug 14th, 2018 10:24PM Aug 14th, 2018 10:24PM Health Care Pharmaceuticals & Biotechnology

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